Thu Aug 22, 2013 - 10:54 am EST
Facing up to vaccines created with aborted fetal cells
August 22, 2013 (MercatorNet) - After decades of ignoring the issue, Nature, the world’s leading science journal, has finally acknowledged that creating life-saving vaccines from tissue from aborted foetuses is a deeply controversial ethical issue.
In 1964, an American researcher obtained cells from a Swedish foetus aborted because her mother already had enough children. He coaxed them into multiplying into a cell line which he called WI-38. Since they were normal and healthy, they were ideal for creating vaccines. Two years later, scientists in the UK obtained cells from a 14-week male fetus aborted for "psychiatric reasons" from a 27-year-old British woman. This cell line is called MRC-5.
It is undeniable that the vaccines made from WI-38 and MRC-5 cells have saved millions of lives. Scientists have made vaccines against rubella, rabies, adenovirus, polio, measles, chickenpox and shingles, as well as smallpox, chicken pox and hepatitis A.
But protests by opponents of abortion have been largely ignored by the scientific community. If you Google “vaccines” and “abortion”, only Catholic groups, right-to-life organisations and sites warning about the dangers of vaccinations mention the topic. The US Centers for Disease Control and Prevention barely alludes to it even though it has abundant information on vaccines. A website called Vaccine Ethics at the University of Pennsylvania Center for Bioethics fails to mention it.
The reason is clear: vaccines save lives and the abortions happened a long time ago. Get over it. Who cares? “At the time [the fetus] was obtained there was no issue in using discarded material. Retrospective ethics is easy but presumptuous,” says Stanley Plotkin, the American scientist who developed the rubella vaccine. “I am fond of saying that rubella vaccine has prevented thousands more abortions than have ever been prevented by Catholic religionists.”
But now even Nature – which supports abortion rights and reproductive technology – has expressed its misgivings. “More than 50 years after the WI-38 cell line was derived from a fetus, science and society [have] still to get to grips with the ethical issues of using human tissue in research,” its editorial declared in June.
What has changed?
If you could single out a reason, it would be the intensely moving 2010 best-seller, The Immortal Life of Henrietta Lacks, by Rebecca Skloot. This book has nothing to do with abortion, but it highlights the deep respect, almost sacredness, that the body of a human person must command, even something as insignificant as discarded tissue.
Henrietta Lacks was an African-American woman who was 31 when she died of cervical cancer in 1951. Cells from her tumour became the first human cells cultured continuously for use in research. HeLa cells have helped to make possible some of the most important medical advances of the past 60 years, including modern vaccines, cancer treatments, and IVF techniques. They are the most widely used human cell lines in existence. More than 300 scientific papers are published every month using HeLa cells.
There is no question about their usefulness – but were they obtained ethically? Is it ethical to continue using them?
The Immortal Life of Henrietta Lacks raises disturbing questions which transcend “usefulness”. Henrietta Lacks was poor and black. Her children, it seems, are even poorer. A doctor at Johns Hopkins removed her cells without asking her. He cultivated the cells without informing her. He distributed the cells without asking permission of her family. Companies became rich by using her cells without paying royalties. Her family only learned that their mother’s cells had been scattered around the world in 1973. Their complaints were ignored for many years – after all, they were only poor, uneducated black folks.
No one cared about the woman called Henrietta Lacks who was overdosed with radium, who died leaving five children behind, one of them an epileptic housed in a filthy, chaotic institution called The Hospital for the Negro Insane. Some people even thought that HeLa cells originated with a woman named Helen Lane. Her daughter wrote in a diary, “When that day came, and my mother died, she was Robbed of her cells and John Hopkins Hospital learned of those cells and kept it to themselfs, and gave them to who they wanted and even changed the name to HeLa cell and kept it from us for 20+ years. They say Donated. No No No Robbed Self.”
It was only earlier this year that the US National Institutes of Health (NIH) negotiated an agreement with the family. All researchers who use or generate full genomic data from HeLa cells must now include in their publications an acknowledgement and expression of gratitude to the Lacks family.
Incredibly, despite all the publicity, scientists continued to ignore the concerns of the Lacks family. Just a few months ago, German researchers published the first sequence of the full HeLa genome. This compromised not only Henrietta Lacks’s genetic privacy but also her family’s. (The researchers have removed the sequence from public view.)
The story of HeLa cells, in short, is twofold: a story of towering scientific achievement and a story of exploitation by ambitious and callous scientists.
Less famous, but even more important, says Nature, have been WI-38 cells. HeLa cells multiply prolifically, but they are cancerous. WI-38 cells are healthy and normal and have been used to develop vaccines against rubella, rabies, adenovirus, polio, measles, chickenpox and shingles. Their origin is even more controversial than the dark story of Henrietta Lacks.
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In 1962 a Swedish woman who was four months pregnant had a legal abortion because she did not want another child. The lungs of the foetus were removed and sent to Philadelphia. At the Wistar Institute for Anatomy and Biology they were minced up, processed and cultured by Leonard Hayflick. He had been culturing cells from aborted foetuses for years, even though abortion was technically illegal in Pennsylvania at the time, except for medical emergencies.
After he successfully multiplied the WI-38 cells, Hayflick created more than 800 batches and distributed them freely around the world to drug companies and researchers. He eventually quarrelled with Wistar authorities because he thought that his contribution was being ignored. Without permission, he took all the remaining batches to California and his new job at Stanford. This led to years of bitter legal battles over who owned the cells. No one worried about where they had come from.
The abortion connection is beyond dispute, although, as Nature points out, “until now, that story has failed to reach the broad audience it deserves.” As in the Henrietta Lacks case, no informed consent was given by the Swedish mother. Her identity is known but she refuses to talk about the case. The doctors involved are all dead. A Swedish medical historian told Nature that in Sweden, “research material like tissues from aborted fetuses were available and used for research without consent or the knowledge of patients for a long time”, both before and after consent rules were tightened later in the 1960s.
The drug companies and institutions which have used WI-38 deny that there are serious ethical concerns either with the use of cells from aborted foetuses or with the lack of consent.
The institution which has examined this issue most closely is the Vatican. In 2005 it released a meticulously researched study of the ethical issues involved in using vaccines which had been developed with tissue from aborted foetuses. Even though it contended that parents could have their children vaccinated with a clear conscience, it did not dismiss the question as irrelevant or absurd. On the contrary, it concluded that “there is a grave responsibility to use alternative vaccines and to make a conscientious objection with regard to those which have moral problems.”
And it said that the existing situation was completely unjust. “Parents… are forced to choose to act against their conscience or otherwise, to put the health of their children and of the population as a whole at risk. This is an unjust alternative choice, which must be eliminated as soon as possible.”
What is the way forward?
I am writing from suburban Sydney which long ago lost its connection to the Aboriginal tribes who once lived here. Yet at every civic ceremony we acknowledge the memory of the Cammeraygal and Wallumedegal peoples. It is a form of reparation for the dispossession, disease and death which carried them away, leaving neither names nor descendants.
Doesn’t the story of Henrietta Lacks suggest that drug companies should do something similar with their vaccine products? From now on, the NIH says, scientists who use HeLa cells must include “an acknowledgment and expression of gratitude to the Lacks family for their contributions”.
Why shouldn’t drug companies and researchers who use the WI-38 (or the MRC-5 cells) do the same? “This vaccine was developed with the cells of a Swedish child who was aborted in 1964. We are grateful for her contribution and grieve at her absence.”Reprinted with permission from Mercatornet.com under a creative commons license.
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