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(Dr. Paul Alexander) – Madmen. They’re real madmen. Why would they create a chimeric SARS-CoV-2 virus with 80% mortality? Is it a bioweapon?
I’m referring to Chen et al., the authors of the pre-print, not yet peer reviewed, breaking abstract called the “Role of spike in the pathogenic & antigenic behavior of SARS-CoV-2 BA.1 2 Omicron.”
Taking this pre-print by Chen et al. at face value, we are looking at a chimera that could potentially wipe out humanity. It is that serious.
This was the same madness we saw when Menachery and Baric et al. posted (see their 2015 paper here) their 2015 paper telling us the insanity of what they had just done, in vitro and in vivo: created the gain-of-function of a very lethal and infectious chimera.
“On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo,” they wrote. “Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.”
Menachery and Baric et al. told us in 2015 that they had just created the very situation we faced with COVID virus, and they did not stop. They went raving mad in 2015 and beyond, inserting furin cleavage sites (a 9 amino acid genetic sequence just in between the junction of the S1 and S2 subunits of the spike glycoprotein) into any and every bat coronavirus and chimera they could produce, stitching together parts of coronaviruses or whole viruses to see the ‘spillover’, that is, the zoonotic jump from animal to human, to test how infectious and lethal they could make the spike.
Yes, they did, and it seems there are more madmen around.
Let’s look at Chen et al.’s stunning breaking 2022 pre-print.
Based on this publication, we have to ask who is funding this dangerous research (not disclosed), and we can now argue that they do not want this crisis to end. This pandemic and this death spiral will continue forever. This pandemic will never end, and I will argue with anyone that this was deliberate. From day one! This was a bioweapon. At this rate, the cycle of COVID illness will not end. We have an infectious sub-variant clade BA.5 with a near zero mortality, and now these madmen create 80% mortality? I want to know why.
READ: Study finds Moderna jabs increase likelihood of COVID infection over time
Let us read slowly what they wrote and try to digest it. Note, they stitched together the present Omicron and initial Wuhan legacy strain in gain-of-function. Note: present Omicron has a lethality of near 0% and, if we accept the findings of Ioannidis, IFR [Infection Fatality Ratio] of 0.05% in those < 70 years or 0.15% across the board. So begin wrapping your head around 80% mortality.
Chen et al. write:
“We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant.”
So these psychos again stitched together parts of other coronaviruses (parts of, or complete viruses: today’s Omicron and the Wuhan legacy that is long gone from the public) and created a new, potentially much more deadly, variant. The question is ‘Why?’ Is anyone policing these crazy idiots? Is this bioweaponry?
And consider this statement:
“The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells.”
This will sound very serious if you re-read it, for at present we have Omicron, which is largely resistant to the vaccinal non-neutralizing induced antibodies that enhance (facilitate) infectiousness in the upper respiratory tract, yet blocks severe illness (virulence, lethality) in the lower respiratory tract. I assume they meant this by the term “distal lung cells.” So have they created a chimera that does not even need to overcome the sub-optimal immune pressure on viral virulence (as Geert Vanden Bossche and myself and others have been warning about), and it can do this NOW? This is potentially catastrophic. Again, this chimera would have an 80% mortality while Omicron still has a near-zero mortality. Why did these people do this?
Consider this statement now:
“In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%.”
You do understand 80% mortality, right? What that looks like compared to the .15% IFR we currently experience with Omicron?
Now read this:
“While these mice develop lung pathology following SARS CoV-2 infection, mortality has been associated with central nervous system involvement due to viral neuroinvasion. The fact that infection with Omi-S, but not with Omicron, elicits neurologic signs, such as hunched posture and lack of responsiveness, in K18-hACE2 mice suggests that the neuroinvasion property is preserved in Omi-S, and the determinants of this property lie outside of the spike protein.”
In other words, not only is this chimera as infectious as the Omicron we have currently circulating today, but it is as pathogenic and deadly as the initial legacy Wuhan strain. It also now introduces a property that we had not seen before or did not dominate: lethal neurological involvement.
We can assume and extrapolate this from the humanized mice like the 8 mice the very FDA and Pfizer used to approve the new bivalent booster.
The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date. The Omicron spike (S) protein, with an unusually large number of mutations, is considered the major driver of these phenotypes.
We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant. The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells. In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. This indicates that while the vaccine escape of Omicron is defined by mutations in S, major determinants of viral pathogenicity reside outside of S.
This is the edited version of a Substack article by Dr. Paul Alexander. Published with permission.
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